GEROVITAL (GH3) Articles (IV)
TREATMENT IN RHEUMATOLOGY By Mircea Dumitru, M.D., Ph.D.
studies present certain peculiarities of the human osteoarticular
with aging: osteopeny, degenerative modifications of the intervertebral
discs, the reduction of the osseous capital. The decline of the muscle
force, (more evident in men,) represents a primordial sign of aging
and begins to manifest after the age of 30. The capacity of muscular
and osteoarticular effort requires a longer adaptation period and
falls may happen during the effort.
normal aging of the osteo-articular system may be appreciated with
the aid of quantitative and qualitative indicators. The bone involution
after the growing period shows that the bone volume diminishes progressively
with the advance in age, with some peculiarities in women. The psychological
osteopenia and the involutive modifications of the other elements
of the osteo-articular system may be accentuated in old people by
proteic, calcic and D vitamin deficiency, in various digestive and
endocrine diseases, or due to iatrogenic causes. Age related changes
in the joint can be found in almost all people over 65. Joints become
increasingly misshapen. Aging of cartilage is associated with biochemical
modifications. The content of water decreases, but proteoglycan content
remains unchanged, thus undergoing changes. Metabolical changes in
cartilage or changes in joint biomechanics make easier the development
of the osteoarthritis process. By its frequency and medico-social
implications, arthritis and rheumatoid arthritis have an important
place in rheumatology.
is the most common form of arthritis in the elderly. Millions of people
suffer from pain, limitation of motion and disability because of osteoarthritis.
There is an exponential increase in arthritis with advancing age.
In the last decades more adult people are suffering degenerative alterations
of joints because of obesity and lack of physical movement. Is there
a relationship between aging and osteoarthritis?
I mentioned, aging is facilitating the development of arthritis, but
the normal changes of the bone and joint are not those of osteoarthritis.
The earliest events in osteoarthritis occur in the cartilage: decreased
total proteoglycan content and shortening of the glucosaminoglycan
branches. The continuity of the surface of cartilage is disrupted.
The most important change in arthritis is the fibrillation of the
cartilage with the focal erosions. In the meantime changes in subchondral
are occurring, leading to a decrease in the density of bone with a
consequent reduction in the mobility of the joint. We do not know
the exact nature of the events that initiate arthritis. Trauma, aging,
occupations, metabolic diseases, lifestyle and genetic factors cause
alterations into the structure of cartilage that facilitate osteoarthritis.
The most common joints that are affected are the hip, knee, carpometacarpal,
and the spine.
clinical use of Gerovital-H3®
studies prove the positive effect of Gerovital-H3® in arthritis
(1,2,3,4,5,6,7,8). I studied 100 subjects suffering from moderate
to severe arthritis admitted to the prophylactic treatment center
at the Nat. Inst. of Gerontology & Geriatrics- Bucharest, 1985
(7). From the beginning in 1946, Prof. Ana Aslan tried to discover
explanations to the complex biological phenomena with special attention
to arthritis. In 1947, Aslan started administering procaine in cases
of trophic troubles of the extremities, sometimes with spectacular
results. This is what she declared;
one injection in the femoral artery, given to a patient with embolism
at the level of the inferior extremity, I noticed the almost instantaneous
disappearance of pain. Then, for the first time, I had the idea to
apply the same method in certain diseases with pain, like rheumatism-specially
at the level of knee articulations- which produces immobilization
and thus long-lasting incapacity".
on, Prof. Aslan used that method of treatment with procaine arterially
administered to patient with arthritis, and she presented the results
obtained with the first 50 cases at a scientific session of the Romanian
Academy back in 1950. Starting in 1949, Aslan started applying procaine
treatment in an old people's home (based on the fact that such patients
present frequent cases of arthritis). Besides an improvement of the
local movement, she noticed an obvious improvement of the physical
and psychological state of the elderly.
then initiated experimental arthritis research which evinced particularly
favorable effects on animals treated with procaine.
Gerovital-H3® has a positive effect on cell metabolism and
on the cell membrane. There are studies where the emphasis was placed
on Gerovital-H3® intervention on the collagen metabolism in arthritis.
Aslan demonstrated the positive effect of her treatment on experimental
arthritis studies (3). In my career, I've treated thousands people
with arthritis all over the world. I studied one group of elderly
people under treatment with Gerovital-H3® suffering from moderate
to severe arthritis involving spine, peripheral joints, hips and knees
was administered one injection daily for 18 days followed by 12 days
of Gerovital-H3® pills daily. I assessed the efficacy of the treatment
comparing pain, joint mobility, functional capacity of the joints
and muscular tone before and after the observation. In parallel, I
noted the psychic mood and the circadian rhythm of blood pressure.
Clinical symptoms like pain and joint mobility have had a remarkable
alleviation in 34%, respectively in 56% and the muscular tone of the
patients was improved in 41%.
want to emphasize that during the Gerovital-H3® treatment no side
effects were noted. The beneficial effect of Gerovital-H3® treatment
is due to its antalgo action, an improvement of capillary permeability
and the favorable intervention in the bioenzymatic disorders at the
level of the joint cartilage. Gerovital-H3® can be the drug of
choice in the management of mild clinical arthritis forms and can
be administered with non-sterodial anti-inflammatory drugs (NSAIDs)
in severe arthritis.
the age of 40, we can start an arthritis' Preventive Treatment with
Gerovital-H3®: one course of 25 pills over 12 days (one pill twice
daily between the meals) and then a 2 week break. The cycle is then
resumed. It is possible to do a milder prophylactic treatment only
with pills in a series of 25 pills during 12 days with an interval
of 45 days in between.
the beginning of arthritis or in a clinically advanced form, I recommended
Curative Treatment: a course of 1 injection daily for 12-days followed
by a 2 week break and then one course of 25 pills over 2 weeks - in
total 6 courses of 12 injections and 5 courses of 25 pills-yearly.
can be individualized; we can shorten or extend the breaks depending
on the results, arthritis gravity and the accompanying diseases. Taking
into consideration cost-results and side effects, with incipient and
mild clinical form of arthritis, Gerovital-H3® treatment is superior
compared to NSAIDs.
arthritis (RA) is a chronic inflammatory arthritis. The clinical features
vary widely ranging from a mild disease to a progressive one. The
pattern is influenced by sex, age, endocrine and genetic factors.
RA may begin in the aged, or may be encountered in an already "old"
form, whose symptoms begin in the adult age. The clinical picture
is more faded, often oligosymptomatical. In many old people, RA is
no longer active and a sick patient presents symptoms and a better
prognosis for seronegative elderly onset. Symptoms such as morning
stiffness, fatigue, weight and appetite loss precede the onset of
RA. Usually, the onset of RA afflict metacarpophalangeal joints and
later on may involve hips, knees and shoulders. Extraarticular symptoms
are rare in old people. At this age we have to differentiate RA from
polymialgia rheumatica, amyloid arthropathy and arthritis.
treatment is indicated in the incipient stage of RA. Its anti-inflammatory
effect is exerted through the AMPc stimulated by the moderate rise
in circulating catecholamine levels in synovia (5,6). Because RA is
a very distressing and an invalidating disease, Gerovital-H3®
with its affects of less fatigue, less stiffness and its antidepressive
effect is beneficial.
back pain afflicts one out of every four adults and old people. Many
of them can not get out of the bed because of Low Back Pain and they
are using anti-inflammatory and pain killing drugs with many side
effects. After surgery within one year 50% to 60% of the patients
will have the same low back and leg pain. The best care of back pain
is the multidisciplinary approach. The loss of disc height is called
disc degeneration and sometimes arthritis. Conservative treatment
should be used before surgery and can be helpful to relieve pains
following back surgery. Gerovital-H3® has a strong indication
in low back pain because of its anti-degenerative effect and to relieve
muscle spasm. Gerovital-H3® is administered locally and I.M. After
a couple of days, the patient is more relaxed and is sleeping better.
To help relieve the pain it is possible to apply Gerovital-H3®
into certain points. For maximum results, the patient has to be treated
daily for the first two weeks. Depending on their condition (arthritis,
degenerative disc, spondylolisthesis, sacroiliac treatment etc.) physical
therapy should also be applied to help take away the swelling that
accompanies the ailments.
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